University of Pittsburgh, Division of Hematology/Oncology, Department of Medicine, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Expert Opin Pharmacother. 2010 Feb;11(3):481-8. doi: 10.1517/14656560903535880.
Mifepristone is a synthetic selective progesterone-receptor modulator (SPRM) that is widely used around the globe in the field of reproductive medicine. At present mifepristone is approved in a number of countries for early termination of pregnancy (TOP), cervical dilatation before surgical TOP, and management of early embryonic loss or fetal death. A number of new clinical applications are being developed in gynecology, endocrinology and oncology. Mifepristone has also served as an invaluable tool in the study of steroid hormone biology.
Current indications for mifepristone are reviewed. New applications for mifepristone under clinical investigation are discussed. In addition, the unique molecular and cellular effects of mifepristone are described.
The reader will understand the mechanisms of action of mifepristone and the underlying steroid hormone biology. The reader will know the approved clinical indications for mifepristone and appreciate the ongoing basic and clinical research into new applications.
Mifepristone is the first-discovered and still most widely used antiprogestin. It has several indications in reproductive medicine and is under investigation for a variety of potential applications in other fields of medicine. The molecular and cellular effects of mifepristone illuminate important aspects of steroid hormone biology.
米非司酮是一种合成的孕激素受体选择性调节剂（SPRMs），在全球生殖医学领域广泛应用。目前，米非司酮在多个国家被批准用于早期终止妊娠（TOP）、手术 TOP 前宫颈扩张以及早期胚胎丢失或胎儿死亡的管理。在妇科、内分泌学和肿瘤学领域正在开发许多新的临床应用。米非司酮也作为类固醇激素生物学研究的宝贵工具。
审查了米非司酮的当前适应证。讨论了正在临床研究中的米非司酮的新应用。此外，还描述了米非司酮独特的分子和细胞作用。
读者将了解米非司酮的作用机制和潜在的类固醇激素生物学。读者将了解米非司酮的批准临床适应证，并欣赏正在进行的基础和临床研究新应用。
米非司酮是第一个发现的、应用最广泛的抗孕激素药物。它在生殖医学中有几个适应证，并且正在被研究用于医学其他领域的多种潜在应用。米非司酮的分子和细胞作用阐明了类固醇激素生物学的重要方面。
Zotero 插件