德国牧羊犬外分泌胰腺功能不全的遗传力。
Heritability of exocrine pancreatic insufficiency in German Shepherd dogs.
机构信息
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland.
出版信息
J Vet Intern Med. 2010 Mar-Apr;24(2):450-2. doi: 10.1111/j.1939-1676.2009.0461.x.
BACKGROUND
Several studies have revealed that exocrine pancreatic insufficiency (EPI) is an inherited disease in German Shepherd Dogs (GSDs). Pedigree analyses have suggested an autosomal recessive inheritance model.
OBJECTIVE
Test mating of 2 dogs with EPI.
ANIMALS
A sire and dam purebred GSD both with EPI and a litter of 6 puppies.
METHODS
Test mating and long-term follow-up of offspring. The pancreas was biopsied via laparotomy on 26 occasions. Serum trypsin-like immunoreactivity was measured. Study was approved by Animal Ethics Committee.
RESULTS
During the 12-year study period only 2 of the 6 offsprings developed pancreatic acinar atrophy (PAA). In 1 puppy, end-stage PAA and in the other puppy partial PAA was diagnosed.
CONCLUSIONS AND CLINICAL IMPORTANCE
PAA is not a congenital disease in GSDs. This study provided evidence that PAA is not inherited in a simple autosomal recessive fashion.
背景
多项研究表明，外分泌胰腺功能不全（EPI）是德国牧羊犬（GSD）的一种遗传性疾病。系谱分析提示其遗传模式为常染色体隐性遗传。
目的
测试 2 只 EPI 犬的交配情况。
动物
一只有 EPI 的公犬和一只有 EPI 的母犬，以及它们的 6 只幼犬。
方法
对后代进行测试交配和长期随访。通过剖腹术对胰腺进行了 26 次活检。测量血清胰蛋白酶样免疫反应性。本研究得到了动物伦理委员会的批准。
结果
在 12 年的研究期间，6 只后代中仅有 2 只发展为胰腺腺泡萎缩（PAA）。在 1 只幼犬中，诊断为终末期 PAA，而另 1 只幼犬则为部分 PAA。
结论和临床意义
PAA 不是 GSD 的先天性疾病。本研究提供的证据表明，PAA 并非以简单的常染色体隐性遗传方式遗传。
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