Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland.
J Vet Intern Med. 2010 Mar-Apr;24(2):450-2. doi: 10.1111/j.1939-1676.2009.0461.x.
Several studies have revealed that exocrine pancreatic insufficiency (EPI) is an inherited disease in German Shepherd Dogs (GSDs). Pedigree analyses have suggested an autosomal recessive inheritance model.
Test mating of 2 dogs with EPI.
A sire and dam purebred GSD both with EPI and a litter of 6 puppies.
Test mating and long-term follow-up of offspring. The pancreas was biopsied via laparotomy on 26 occasions. Serum trypsin-like immunoreactivity was measured. Study was approved by Animal Ethics Committee.
During the 12-year study period only 2 of the 6 offsprings developed pancreatic acinar atrophy (PAA). In 1 puppy, end-stage PAA and in the other puppy partial PAA was diagnosed.
PAA is not a congenital disease in GSDs. This study provided evidence that PAA is not inherited in a simple autosomal recessive fashion.
多项研究表明，外分泌胰腺功能不全（EPI）是德国牧羊犬（GSD）的一种遗传性疾病。系谱分析提示其遗传模式为常染色体隐性遗传。
测试 2 只 EPI 犬的交配情况。
一只有 EPI 的公犬和一只有 EPI 的母犬，以及它们的 6 只幼犬。
对后代进行测试交配和长期随访。通过剖腹术对胰腺进行了 26 次活检。测量血清胰蛋白酶样免疫反应性。本研究得到了动物伦理委员会的批准。
在 12 年的研究期间，6 只后代中仅有 2 只发展为胰腺腺泡萎缩（PAA）。在 1 只幼犬中，诊断为终末期 PAA，而另 1 只幼犬则为部分 PAA。
PAA 不是 GSD 的先天性疾病。本研究提供的证据表明，PAA 并非以简单的常染色体隐性遗传方式遗传。
