Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, China.
Clin Chim Acta. 2010 Apr 2;411(7-8):581-3. doi: 10.1016/j.cca.2010.01.022. Epub 2010 Jan 25.
Tetranectin (TN) is a plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. A previous proteomics study identified TN in the cerebrospinal fluid (CSF) of epileptic patients but not in healthy controls. We determined the concentrations of TN in CSF and serum of epileptic patients to evaluate the changes in TN levels after epileptic attack.
We detected TN in the CSF and serum of 64 epileptic patients and 26 healthy subjects using sandwich enzyme-linked immunosorbent assays.
Compared with the control group, CSF-TN levels increased in epileptic patients while serum-TN levels decreased. These differences were statistically significant. The decrease of serum-TN in patients with drug-refractory epilepsy was the most striking.
CSF-TN and serum-TN are potential biomarkers in epilepsy and drug-refractory epilepsy and would be useful for diagnosis.
Tetranectin（TN）是一种纤溶酶原kringle4 结合蛋白，通过与纤溶酶原结合来调节纤维蛋白溶解和蛋白水解过程。先前的蛋白质组学研究在癫痫患者的脑脊液（CSF）中发现了 TN，但在健康对照组中未发现。我们测定了癫痫患者 CSF 和血清中的 TN 浓度，以评估癫痫发作后 TN 水平的变化。
我们使用夹心酶联免疫吸附试验检测了 64 例癫痫患者和 26 例健康受试者的 CSF 和血清中的 TN。
与对照组相比，癫痫患者的 CSF-TN 水平升高，而血清-TN 水平降低。这些差异具有统计学意义。耐药性癫痫患者的血清-TN 下降最为明显。
CSF-TN 和血清-TN 是癫痫和耐药性癫痫的潜在生物标志物，有助于诊断。
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