Iram Sana, Rahman Safikur, Choi Inho, Kim Jihoe
Department of Medical Biotechnology and Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Department of Botany, Munshi Singh College, BR Ambedkar Bihar University, Muzaffarpur, Bihar, 845401, India.
Heliyon. 2023 Dec 10;10(1):e23512. doi: 10.1016/j.heliyon.2023.e23512. eCollection 2024 Jan 15.
Tetranectin (TN), a serum protein, is closely associated with different types of cancers. TN binds plasminogen and promotes the proteolytic activation of plasminogen into plasmin, which suggests that TN is involved in remodeling the extracellular matrix and cancer tissues during cancer development. TN is also associated with other diseases, such as developmental disorders, cardiovascular diseases, neurological diseases, inflammation, and diabetes. Although the functional mechanism of TN in diseases is not fully elucidated, TN binds different proteins, such as structural protein, a growth factor, and a transcription regulator. Moreover, TN changes and regulates protein functions, indicating that TN-binding proteins mediate the association between TN and diseases. This review summarizes the current knowledge of TN-associated diseases and TN functions with TN-binding proteins in different diseases. In addition, potential TN-targeted disease treatment by inhibiting the interaction between TN and its binding proteins is discussed.
四连蛋白（TN）是一种血清蛋白，与不同类型的癌症密切相关。TN结合纤溶酶原并促进纤溶酶原向纤溶酶的蛋白水解激活，这表明TN在癌症发展过程中参与细胞外基质和癌组织的重塑。TN还与其他疾病相关，如发育障碍、心血管疾病、神经疾病、炎症和糖尿病。尽管TN在疾病中的功能机制尚未完全阐明，但TN可结合不同的蛋白质，如结构蛋白、生长因子和转录调节因子。此外，TN可改变并调节蛋白质功能，这表明TN结合蛋白介导了TN与疾病之间的关联。本文综述了目前关于TN相关疾病以及TN在不同疾病中与TN结合蛋白的功能的认识。此外，还讨论了通过抑制TN与其结合蛋白之间的相互作用进行潜在的TN靶向疾病治疗。
