Aprile C, Prati U, Saponaro R, Roveda L, Carena M, Gastaldo L
Fond. Clinica del Lavoro, IRCCS-Nuclear Medicine Service, Pavia, Italy.
Int J Rad Appl Instrum B. 1991;18(1):51-2. doi: 10.1016/0883-2897(91)90046-n.
Thirty-two immunoscintigraphic studies have been performed in 26 patients previously operated upon for rectosigmoid cancer, for an early detection of pelvic recurrence, employing 111In anti-CEA, F(ab')2. The sensitivity was 1, specificity 0.76 and accuracy 0.84, leading to a positive predictive value of 0.69 and a negative value of 1. The combined use of a non-imaging surgical probe in 6 of the 10 patients who underwent second look surgery, detecting the 111In radioactivity used for RIS, improved diagnostic accuracy, ruling out the presence of tumors in 3 patients with false positive RIS.
对26例曾接受过直肠乙状结肠癌手术的患者进行了32次免疫闪烁扫描研究，采用铟-111标记的抗癌胚抗原F(ab')2来早期检测盆腔复发。敏感性为1，特异性为0.76，准确性为0.84，阳性预测值为0.69，阴性预测值为1。在10例接受二次探查手术的患者中，有6例联合使用了非成像手术探头，检测用于免疫闪烁扫描的铟-111放射性，提高了诊断准确性，排除了3例免疫闪烁扫描假阳性患者存在肿瘤的情况。
