Finn R, Cheung N K, Divgi C, St Germain J, Graham M, Pentlow K, Larson S M
Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Rad Appl Instrum B. 1991;18(1):9-13. doi: 10.1016/0883-2897(91)90040-r.
Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.
许多物理和化学因素都会影响化合物的放射性标记。当尝试用短寿命的正电子发射放射性核素对单克隆抗体进行标记时，这些因素增加了复杂性的新维度。对与掺入合成前体中的放射性核素相关的独特化学分离缺乏认识，往往会导致意想不到的或不可重复的结果。
