Villar Cristina C, Cochran David L
Department of Periodontics, The University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7894, San Antonio, TX 78229-3900, USA.
Dent Clin North Am. 2010 Jan;54(1):73-92. doi: 10.1016/j.cden.2009.08.011.
The concept that only fibroblasts from the periodontal ligament or undifferentiated mesenchymal cells have the potential to re-create the original periodontal attachment has been long recognized. Based on this concept, guided tissue regeneration has been applied with variable success to regenerate periodontal defects. Quantitative analysis of clinical outcomes after guided tissue regeneration suggests that this therapy is a successful and predictable procedure to treat narrow intrabony defects and class II mandibular furcations, but offers limited benefits in the treatment of other types of periodontal defects.
长期以来，人们一直认为只有来自牙周膜的成纤维细胞或未分化的间充质细胞才有潜力重新形成原始的牙周附着。基于这一概念，引导组织再生已被应用于牙周缺损的再生，取得了不同程度的成功。引导组织再生后临床结果的定量分析表明，这种治疗方法是治疗窄骨内缺损和Ⅱ度下颌根分叉病变的一种成功且可预测的方法，但在治疗其他类型的牙周缺损方面益处有限。
