Corfield D R, Deffebach M E, Erjefält I, Salonen R O, Webber S E, Widdicombe J G
Department of Physiology, St. George's Hospital Medical School, London, United Kingdom.
J Appl Physiol (1985). 1991 Jan;70(1):274-81. doi: 10.1152/jappl.1991.70.1.274.
Blood flow in the tracheal mucosa (Qm) has been measured by laser-Doppler flowmetry in anesthetized sheep and dogs. The values have been compared with tracheal arterial inflow (Qtr) by use of an electromagnetic flow probe and with tracheal arterial perfusion pressure (Ptr) produced by mechanical perfusion. Changes in blood flow were caused by injections of methacholine, phenylephrine, and histamine into the perfusion circuit. These interventions produced a range of measurements for each animal. Correlations of Qm against Qtr were significant in two of five animals (R = 0.03-0.93); correlations of Qm against Ptr were significant in two of four animals (R = 0.56-0.96). Percent changes in Qtr were generally much larger than those of Qm, and there was considerable variability between Qm and either Qtr or Ptr. Qm reflected the same vascular changes as Ptr or Qtr in 28 interventions and showed an opposing change in 4 cases. In 11 interventions, changes measured by Ptr or Qtr were not reflected by any changes in Qm. Thus qualitative changes in tracheal perfusion measured with these methods were usually the same; quantitatively the three methods showed great differences. These differences may reflect different regulatory mechanisms in various components of the tracheal vasculature or different technical aspects of the methods used.
已通过激光多普勒血流仪在麻醉的绵羊和犬中测量了气管黏膜中的血流量（Qm）。通过使用电磁血流探头将这些值与气管动脉流入量（Qtr）进行了比较，并与机械灌注产生的气管动脉灌注压（Ptr）进行了比较。通过向灌注回路中注射乙酰甲胆碱、去氧肾上腺素和组胺来引起血流变化。这些干预措施为每只动物产生了一系列测量值。五分之二的动物中Qm与Qtr的相关性显著（R = 0.03 - 0.93）；四分之二的动物中Qm与Ptr的相关性显著（R = 0.56 - 0.96）。Qtr的百分比变化通常比Qm的变化大得多，并且Qm与Qtr或Ptr之间存在相当大的变异性。在28次干预中，Qm反映的血管变化与Ptr或Qtr相同，在4例中显示出相反的变化。在11次干预中，Ptr或Qtr测量的变化未被Qm的任何变化所反映。因此，用这些方法测量的气管灌注的定性变化通常是相同的；在定量方面，这三种方法显示出很大差异。这些差异可能反映了气管血管系统各个组成部分中不同的调节机制或所用方法的不同技术方面。
