癌症中 H3K27 甲基化的失调。
Deregulation of H3K27 methylation in cancer.
出版信息
Nat Genet. 2010 Feb;42(2):100-1. doi: 10.1038/ng0210-100.
PMID:20104248
Abstract
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.
摘要
一项新的研究报告称，在弥漫性大 B 细胞淋巴瘤（DLBCL）中，组蛋白甲基转移酶 EZH2 的体细胞突变会频繁发生，该酶可修饰 H3K27。目前有证据表明，控制 H3K27 甲基化的酶的活性既有增加也有减少，这表明这种甲基化的精确平衡对正常细胞的生长至关重要。
Zotero 插件