Department of Cerebrovascular Disease, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565 Japan.
Eur J Neurosci. 2010 Jan;31(1):90-8. doi: 10.1111/j.1460-9568.2009.07043.x.
Increasing evidence points to accelerated neurogenesis after stroke, and support of such endogenous neurogenesis has been shown to improve stroke outcome in experimental animal models. The present study analyses post-stroke cerebral cortex after cardiogenic embolism in autoptic human brain. Induction of nestin- and musashi-1-positive cells, potential neural stem/progenitor cells, was observed at the site of ischemic lesions from day 1 after stroke. These two cell populations were present at distinct locations and displayed different temporal profiles of marker expression. However, no surviving differentiated mature neural cells were observed by 90 days after stroke in the previously ischemic region. Consistent with recent reports of neurogenesis in the cerebral cortex after induction of stroke in rodent models, the present current data indicate the presence of a regional regenerative response in human cerebral cortex. Furthermore, observations underline the potential importance of supporting survival and differentiation of endogenous neural stem/progenitor cells in post-stroke human brain.
越来越多的证据表明中风后神经发生加速，并且支持这种内源性神经发生已被证明可以改善实验动物模型中的中风预后。本研究分析了心源性栓塞后中风患者尸检人脑的大脑皮质。在中风后第 1 天，即可在缺血性病变部位观察到巢蛋白和 Musashi-1 阳性细胞（潜在的神经干细胞/祖细胞）的诱导。这两个细胞群位于不同的位置，并且表现出不同的标记物表达的时间特征。然而，在中风后 90 天，在先前的缺血区域未观察到存活的分化成熟的神经细胞。与最近在啮齿动物模型中诱导中风后大脑皮层神经发生的报道一致，本研究数据表明人类大脑皮层存在区域性再生反应。此外，这些观察结果强调了支持中风后人类大脑内源性神经干细胞/祖细胞存活和分化的重要性。
