Alman B A, Goldberg M J
Department of Orthopaedics, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
J Pediatr Orthop. 1991 Mar-Apr;11(2):181-3. doi: 10.1097/01241398-199103000-00007.
There are no clinicopathologic reports of solitary osteochondroma of the clavicle other than listings in tumor registries. Two boys had solitary asymptomatic osteochondroma, in one at the medial and in the other at the lateral aspect of the clavicle. One underwent excision to correct cosmetic deformity. Several histologic and experimental studies have shown that osteochondromas originate from cells of the growth plate. During development of the clavicle, cartilage appears on both the medial and lateral aspects. Histologic studies have suggested that this cartilage is similar to a physeal growth plate. Experimental studies, however, have shown it to be a randomly organized secondary cartilage that develops in membranous bones once ossification has begun. The occurrence of an osteochondroma at the ends of the clavicle lends support to the theory that the cartilage at the ends of the developing clavicle functions as a growth plate.
除了肿瘤登记处的记录外，尚无关于锁骨孤立性骨软骨瘤的临床病理报告。两名男孩患有孤立性无症状骨软骨瘤，其中一名位于锁骨内侧，另一名位于锁骨外侧。其中一人接受了切除手术以纠正外观畸形。多项组织学和实验研究表明，骨软骨瘤起源于生长板细胞。在锁骨发育过程中，内侧和外侧均会出现软骨。组织学研究表明，这种软骨类似于骨骺生长板。然而，实验研究表明，它是一种随机组织的继发性软骨，在骨化开始后在膜性骨中发育。锁骨末端出现骨软骨瘤支持了这样一种理论，即发育中的锁骨末端的软骨起到生长板的作用。
