Department of Medicine I, Medical University Innsbruck, 6020 Innsbruck, Austria.
Eur J Clin Invest. 2010 Mar;40(3):277-80. doi: 10.1111/j.1365-2362.2010.02255.x. Epub 2010 Jan 25.
Subclinical inflammation in obesity is critical for development of several obesity-associated disorders. We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms.
Thirty-two obese patients undergoing bariatric surgery were tested before and on an average of 18 months after gastric banding or gastric bypass surgery.
Pronounced weight loss after bariatric surgery was accompanied by improvements in parameters of lipid and glucose metabolism and increased adiponectin levels. Chemoattractant chemerin significantly decreased from 175.91 +/- 24.50 to 145.53 +/- 26.44 ng mL(-1) after bariatric surgery (P < or = 0.01). Concomitantly, hs-CRP as a marker of subclinical inflammation was significantly reduced after weight reduction (P < or = 0.01).
We hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects.
肥胖症中的亚临床炎症对几种与肥胖相关的疾病的发展至关重要。我们着手研究明显的体重减轻对循环趋化素水平的影响，趋化素是一种趋化蛋白，也通过旁分泌和自分泌机制影响脂肪细胞功能。
32 名接受减肥手术的肥胖患者在胃带或胃旁路手术前和平均 18 个月后进行了检测。
减肥手术后明显的体重减轻伴随着脂质和葡萄糖代谢参数的改善和脂联素水平的增加。趋化素趋化素从减肥手术后的 175.91 +/- 24.50 降至 145.53 +/- 26.44 ng mL(-1)（P < or = 0.01）。同时，hs-CRP 作为亚临床炎症的标志物在体重减轻后显著降低（P < or = 0.01）。
我们假设，体重减轻引起的循环趋化素减少可能与脂肪组织中巨噬细胞募集减少和亚临床炎症减轻有关，这再次部分解释了肥胖患者体重减轻的长期有益效果。
