Department of Paediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore 119074, Singapore.
Vaccine. 2010 Mar 19;28(14):2577-9. doi: 10.1016/j.vaccine.2010.01.020. Epub 2010 Jan 25.
Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules.
益生菌已被证明可增强疫苗的特定免疫应答。我们旨在评估益生菌补充剂对婴儿乙型肝炎（HepB）疫苗接种特异性 IgG 抗体应答的影响。与对照组相比，在接受单剂 HepB 疫苗（0、1 个月）和 DTPa-HepB 联合疫苗（6 个月）的受试者中，益生菌补充剂可改善 HepB 表面抗体应答[安慰剂（n=28）：187.97（180.70-195.24），益生菌（n=29）：345.70（339.41-351.99）mIU/ml]（p=0.069），但对接受 3 剂单价疫苗的受试者无影响[安慰剂（n=68）：302.34（296.31-308.37），益生菌（n=77）：302.06（296.31-307.81）mIU/ml]（p=0.996）。益生菌可能增强某些乙型肝炎疫苗接种方案中婴儿的特定抗体应答。
