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再生医学:外科医生的视角。

Regenerative medicine: a surgeon's perspective.

机构信息

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA 94305-5148, USA.

出版信息

J Pediatr Surg. 2010 Jan;45(1):11-7; discussion 17-8. doi: 10.1016/j.jpedsurg.2009.10.004.

Abstract

More than 200 million incisions are made in the world each year on children and adults. They all end up with a scar unless there is an unusual situation where we are operating on an early gestation fetus. The question is, "why do we not regenerate?" and "why do we always heal with either a 'normal amount of scarring' or, approximately 15% of the time, with a pathologic amount of scarring (hypertrophic scar or keloid)?"

摘要

每年全球有超过 2 亿例儿童和成人接受手术切口。除了在妊娠早期为胎儿进行手术的特殊情况外,所有切口最终都会留下疤痕。问题是,“为什么我们不能再生?”以及“为什么我们的愈合总是呈现‘正常量的疤痕’或大约 15%的时间呈现病理性疤痕(增生性疤痕或瘢痕疙瘩)?”

相似文献

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Regenerative medicine: a surgeon's perspective.再生医学:外科医生的视角。
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本文引用的文献

1
Generation of induced pluripotent stem cells using recombinant proteins.利用重组蛋白生成诱导多能干细胞。
Cell Stem Cell. 2009 May 8;4(5):381-4. doi: 10.1016/j.stem.2009.04.005. Epub 2009 Apr 23.
2
Wound repair and regeneration.伤口修复与再生。
Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039.
4
Induced pluripotent stem cell lines derived from human somatic cells.源自人类体细胞的诱导多能干细胞系。
Science. 2007 Dec 21;318(5858):1917-20. doi: 10.1126/science.1151526. Epub 2007 Nov 20.

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