Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA 94305-5148, USA.
J Pediatr Surg. 2010 Jan;45(1):11-7; discussion 17-8. doi: 10.1016/j.jpedsurg.2009.10.004.
More than 200 million incisions are made in the world each year on children and adults. They all end up with a scar unless there is an unusual situation where we are operating on an early gestation fetus. The question is, "why do we not regenerate?" and "why do we always heal with either a 'normal amount of scarring' or, approximately 15% of the time, with a pathologic amount of scarring (hypertrophic scar or keloid)?"
每年全球有超过 2 亿例儿童和成人接受手术切口。除了在妊娠早期为胎儿进行手术的特殊情况外,所有切口最终都会留下疤痕。问题是,“为什么我们不能再生?”以及“为什么我们的愈合总是呈现‘正常量的疤痕’或大约 15%的时间呈现病理性疤痕(增生性疤痕或瘢痕疙瘩)?”