儿童和青少年的出生体重、糖尿病家族史和代谢综合征。

Birth weight, family history of diabetes, and metabolic syndrome in children and adolescents.

机构信息

Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.

出版信息

J Pediatr. 2010 May;156(5):719-23, 723.e1. doi: 10.1016/j.jpeds.2009.11.043. Epub 2010 Jan 27.

DOI:10.1016/j.jpeds.2009.11.043

PMID:20106489

Abstract

OBJECTIVE

To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.

STUDY DESIGN

A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.

RESULTS

In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.

CONCLUSIONS

HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.

摘要

目的

评估糖尿病家族史（FHD）和低出生体重（LBW）或高出生体重（HBW）与儿童和青少年代谢综合征（MetS）之间的关系。

研究设计

本研究为一项横断面、基于社区的研究，共随机选择了 1262 名 7-15 岁的儿童和青少年入组。

结果

在总体人群中，HBW（比值比[OR] = 1.4；95%置信区间[CI] = 1.2-10.9），而不是 LBW（OR = 0.97；95% CI = 0.6-2.1），与 MetS 显著相关。在没有 FHD 的组中，HBW（OR = 1.730；95% CI = 1.1-2.7），而不是 LBW（OR = 1.139；95% CI = 0.7-23），与 MetS 相关。在有 FHD 的组中，LBW（OR = 2.690；95% CI = 1.4-15.1）和 HBW（OR = 3.289；95% CI = 1.3-30.6）均与 MetS 相关。LBW（OR = 4.710；95% CI = 1.4-39.7）和 HBW（OR = 3.127；95% CI = 1.3-45.1）与 FHD 阳性的母系后代的 MetS 相关，但在父系后代中则没有相关性。