Egan Aoife M, Enninga Elizabeth Ann L, Alrahmani Layan, Weaver Amy L, Sarras Michael P, Ruano Rodrigo
Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
J Clin Med. 2021 Feb 3;10(4):569. doi: 10.3390/jcm10040569.
Gestational diabetes mellitus (GDM) is a frequently observed complication of pregnancy and is associated with an elevated risk of adverse maternal and neonatal outcomes. Many women with GDM will go on to have future pregnancies, and these pregnancies may or may not be affected by GDM. We conducted a literature search, and based on data from key studies retrieved during the search, we describe the epidemiology of GDM recurrence. This includes a summary of the observed clinical risk factors of increasing maternal age, weight, ethnicity, and requirement for insulin in the index pregnancy. We then present our data from Mayo Clinic (January 2013-December 2017) which identifies a GDM recurrence rate of 47.6%, and illustrates the relevance of population-based studies to clinical practice. Lastly, we examine the available evidence on strategies to prevent GDM recurrence, and note that more research is needed to evaluate the effect of interventions before, during and after pregnancy.
妊娠期糖尿病（GDM）是一种常见的妊娠并发症，与孕产妇和新生儿不良结局风险升高相关。许多患有GDM的女性会再次怀孕，这些妊娠可能会或可能不会受到GDM的影响。我们进行了文献检索，并根据检索过程中获取的关键研究数据，描述了GDM复发的流行病学情况。这包括对观察到的孕产妇年龄增加、体重、种族以及本次妊娠中胰岛素需求增加等临床风险因素的总结。然后，我们展示了梅奥诊所（2013年1月至2017年12月）的数据，该数据显示GDM复发率为47.6%，并说明了基于人群的研究与临床实践的相关性。最后，我们研究了关于预防GDM复发策略的现有证据，并指出需要更多研究来评估孕前、孕期和产后干预措施的效果。
