Mishunina T M, Mestechkina A Ia, Lisak V F
Ukr Biokhim Zh. 1977 Nov-Dec;49(6):12-18.
Adrenalectomy is accompanied by a decreased content of free amino acids in muscules and blood plasma by an increased content of certain amino acids in the liver. A single injection of hydrocortisone to adrenalectomized animals increases the content of amino acids in muscles and lowers their total content in the liver; a single injection of ACTH lowers the total content of amino acids in the liver and blood plasma "Substitutive therapy" by hydrocortisone essentially increases the content of amino acids in the liver, muscles and blood plasma. Under conditions of the experiment the least changes in the content of amino acids were found in the brain tissue.
肾上腺切除术会导致肌肉和血浆中游离氨基酸含量降低，同时肝脏中某些氨基酸含量增加。给肾上腺切除的动物单次注射氢化可的松会增加肌肉中氨基酸的含量，并降低肝脏中氨基酸的总含量；单次注射促肾上腺皮质激素会降低肝脏和血浆中氨基酸的总含量。氢化可的松的“替代疗法”本质上会增加肝脏、肌肉和血浆中氨基酸的含量。在实验条件下，脑组织中氨基酸含量的变化最小。
