Department of Orthopaedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
Med Hypotheses. 2010 Jun;74(6):1067-8. doi: 10.1016/j.mehy.2009.12.024. Epub 2010 Jan 27.
Osteoporosis is a serious health problem worldwide and leads to a significant burden on society. Unfortunately, efforts to control osteoporosis are largely unsuccessful. Lowering an individual's risk for osteoporosis must focus not only on treatment but also on modification of risk factors. One of the common risk factors is smoking tobacco. Here, we review the clinical evidence on nicotine consumption and osteoporosis, and propose a possible protective mechanism. It should be note that there is no strong clinical evidence that proves nicotine is detrimental. Studies also indicated that the prime criminal for osteoporosis is smoking not nicotine. Moreover, low level nicotine has preventive efforts on osteoporosis by stimulating osteoblasts proliferation and differentiation. We present a hypothesis that low level nicotine may be a novel approach to reduce osteoporosis incidence.
骨质疏松症是一个全球性的严重健康问题，给社会带来了巨大的负担。不幸的是，控制骨质疏松症的努力在很大程度上是不成功的。降低个体患骨质疏松症的风险不仅要注重治疗，还要注重危险因素的改变。常见的危险因素之一是吸烟。在这里，我们回顾了尼古丁摄入与骨质疏松症的临床证据，并提出了一种可能的保护机制。值得注意的是，没有强有力的临床证据证明尼古丁是有害的。研究还表明，导致骨质疏松症的主要元凶是吸烟而不是尼古丁。此外，低水平尼古丁通过刺激成骨细胞增殖和分化对骨质疏松症有预防作用。我们提出了一个假设，即低水平尼古丁可能是降低骨质疏松症发病率的一种新方法。
