Grazio Simeon
Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju, Klinicka bolnica Sestre milosrdnice, Vinogradska 29, 10000 Zagreb.
Reumatizam. 2006;53(2):18-31.
Osteoporosis represents a major and increasing public health problem with the aging of population. Major clinical consequences and economic burden of the disease are fractures. Many risk factors are associated with the fractures including low bone mass, hormonal disorders, personal and family history of fractures, low body weight, use of certain drugs (e.g. glucocorticoids), cigarette smoking, elevated intake of alchohol, low physical activity, insufficient level of vitamin D and low intake of calcium. This epidemiological review describes frequency, importance of risk factors and impact of osteoporosis and osteoporotic fractures. Objective measures of bone mineral density along with clinical assessment of risk factors can help identify patients who will benefit from prevention and intervention efforts and eventually reduce the morbidity and mortality associated with osteoporosis-related fractures.
随着人口老龄化,骨质疏松症已成为一个日益严重的重大公共卫生问题。该疾病的主要临床后果和经济负担是骨折。许多风险因素与骨折相关,包括低骨量、激素紊乱、个人及家族骨折史、低体重、使用某些药物(如糖皮质激素)、吸烟、酒精摄入量高、身体活动不足、维生素D水平不足以及钙摄入量低。这篇流行病学综述描述了骨质疏松症和骨质疏松性骨折的发病率、风险因素的重要性及其影响。骨密度的客观测量以及风险因素的临床评估有助于识别那些将从预防和干预措施中受益的患者,并最终降低与骨质疏松症相关骨折的发病率和死亡率。