Medical Physics and Applied Radiation Science, McMaster University, Hamilton, L8S 4K1, Canada.
Phys Med Biol. 2010 Feb 21;55(4):1083-98. doi: 10.1088/0031-9155/55/4/012. Epub 2010 Jan 28.
The interpretation of measurements of bone strontium in vivo using energy dispersive x-ray fluorescence spectroscopy is presently hindered by overlying skin and soft-tissue absorption of the strontium x-rays. The use of imaging technologies to measure the overlying soft-tissue thickness at the index finger measuring site might allow correction of the strontium reading to estimate its concentration in bone. An examination of magnetic resonance (MR), computed tomography (CT) and high-frequency ultrasound (US) imaging technologies revealed that 55 MHz US had the smallest range of measurement uncertainty at 3.2% followed by 1 Tesla MR, 25 MHz US, 8 MHz US and CT at 4.3, 5.4, 6.6 and 7.1% uncertainty, respectively. Of these, only CT imaging appeared to underestimate total thickness (p < 0.05). Furthermore, an inter-study comparison on the accuracy of US measurements of the overlying tissue thickness at finger and ankle in nine subjects was investigated. The 8 MHz US system used in prior in vivo experiments was found to perform satisfactorily in a repeat study of ankle measurements, but indicated that finger thickness measurements may have been misread in previous studies by up to 17.7% (p < 0.025). Repeat ankle measurements were not significantly different from initial measurements at 2.2% difference.
目前，使用能量色散 X 射线荧光光谱法对体内骨锶的测量进行解释受到表层皮肤和软组织对锶 X 射线的吸收的阻碍。使用成像技术测量食指测量部位的上层软组织厚度，可能可以校正锶读数，以估计其在骨骼中的浓度。对磁共振（MR）、计算机断层扫描（CT）和高频超声（US）成像技术的检查表明，55 MHz US 的测量不确定度范围最小，为 3.2%，其次是 1 Tesla MR、25 MHz US、8 MHz US 和 CT，分别为 4.3%、5.4%、6.6%和 7.1%。在这些技术中，只有 CT 成像似乎低估了总厚度（p<0.05）。此外，还研究了在九名受试者中手指和脚踝的上层组织厚度的 US 测量的准确性的研究间比较。先前在体内实验中使用的 8 MHz US 系统在脚踝测量的重复研究中表现良好，但表明手指厚度测量可能在前些研究中被误读了多达 17.7%（p<0.025）。重复脚踝测量与初始测量的差异不显著，为 2.2%。
