Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton L8S 4K1, Canada.
Department of Physics, Ryerson University, Toronto M5B 2K3, Canada.
Bone. 2014 Apr;61:48-54. doi: 10.1016/j.bone.2014.01.002. Epub 2014 Jan 14.
Ten female volunteers were recruited as part of the Ryerson and McMaster University Strontium (Sr) in Bone Research Study to have their bone Sr levels measured as they self-supplemented with Sr supplements of their choice. Of the ten volunteers, nine were suffering from osteopenia and/or osteoporosis. Non-invasive bone Sr measurements were performed using an in vivo x-ray fluorescence (IVXRF) I-125 based system. Thirty minute measurements were taken at the finger and ankle, representing primarily cortical and trabecular bone, respectively. For analysis, the 14.2keV Sr K-alpha peak normalized to the Coherent peak at 35.5keV was used. Baseline readings, representing natural bone Sr levels were acquired since all volunteers had no previous intake of Sr based supplements or medications. Once Sr supplements were started, a 24h reading was taken, followed by frequent measurements ranging from weekly, biweekly to monthly. The longest volunteer participation was 1535days. The mean baseline Sr signal observed for the group was 0.42±0.13 and 0.39±0.07 for the finger and ankle, respectively. After 24h, the mean Sr signal rose to 1.43±1.12 and 1.17±0.51, for the finger and ankle, respectively, representing a statistically significant increase (p=0.0043 & p=0.000613). Bone Sr levels continued to increase throughout the length of the study. However the Sr signal varied widely between the individuals such that after three years, the highest Sr signal observed was 28.15±0.86 for the finger and 26.47±1.22 for the ankle in one volunteer compared to 3.15±0.15 and 4.46±0.36, for the finger and ankle, respectively in another. Furthermore, while it was previously reported by our group, that finger bone Sr levels may plateau within two years, these results suggest otherwise, indicating that bone Sr levels will continue to rise at both bone sites even after 4years of Sr intake.
招募了 10 名女性志愿者参加瑞尔森大学和麦克马斯特大学的锶（Sr）在骨骼研究中的研究，以自行补充他们选择的 Sr 补充剂，测量他们的骨骼 Sr 水平。在这 10 名志愿者中，有 9 人患有骨质疏松症和/或骨质疏松症。使用基于体内 X 射线荧光（IVXRF）I-125 的系统进行非侵入性骨骼 Sr 测量。在手指和脚踝处进行 30 分钟的测量，分别代表皮质骨和小梁骨。进行分析时，使用归一化为 35.5keV 相干峰的 14.2keV Sr K-alpha 峰。由于所有志愿者均未服用基于 Sr 的补充剂或药物，因此获得了代表自然骨骼 Sr 水平的基线读数。开始 Sr 补充剂后，将进行 24 小时读数，然后进行频繁测量，从每周、每两周到每月不等。志愿者的最长参与时间为 1535 天。该组观察到的平均基线 Sr 信号为 0.42±0.13 和 0.39±0.07，分别为手指和脚踝。24 小时后，手指和脚踝的 Sr 信号分别升高至 1.43±1.12 和 1.17±0.51，呈统计学显著增加（p=0.0043 和 p=0.000613）。在整个研究过程中，骨骼 Sr 水平持续增加。但是，个体之间的 Sr 信号差异很大，以至于在三年后，一名志愿者的手指 Sr 信号最高，为 28.15±0.86，而脚踝为 26.47±1.22，而另一名志愿者的手指和脚踝的 Sr 信号分别为 3.15±0.15 和 4.46±0.36。此外，尽管我们小组之前曾报道过手指骨 Sr 水平可能在两年内达到平台期，但这些结果表明并非如此，表明即使在 4 年 Sr 摄入后，两个骨骼部位的骨骼 Sr 水平仍将继续上升。
