Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
J Thorac Oncol. 2010 Apr;5(4):417-9. doi: 10.1097/JTO.0b013e3181ce3afd.
The signaling pathway mediated by transforming growth factor-beta (TGF-beta) participates in various biologic processes, including cell growth, differentiation, angiogenesis, apoptosis, and extracellular matrix remodeling. In the context of cancer, TGF-beta signaling can inhibit tumor growth in early-stage tumors. However, in late-stage tumors, the very same pathway promotes tumor invasiveness and metastasis. This paradoxical effect is mediated through similar to mothers against decapentaplegic or Smad protein dependent and independent mechanisms and provides an opportunity for targeted cancer therapy. This review summarizes the molecular process of TGF-beta signaling and the changes in inhibitory Smads that contribute to lung cancer progression. We also present current approaches for rational therapies that target the TGF-beta signaling pathway in cancer.
转化生长因子-β（TGF-β）介导的信号通路参与多种生物学过程，包括细胞生长、分化、血管生成、凋亡和细胞外基质重塑。在癌症的背景下，TGF-β信号通路可以抑制早期肿瘤的生长。然而，在晚期肿瘤中，同样的通路促进肿瘤的侵袭和转移。这种矛盾的效应是通过类似母亲抗 decapentaplegic 或 Smad 蛋白依赖和非依赖的机制介导的，为靶向癌症治疗提供了机会。本文总结了 TGF-β信号通路的分子过程以及抑制性 Smad 蛋白的变化在促进肺癌进展中的作用。我们还介绍了目前针对癌症中 TGF-β信号通路的合理治疗方法。
