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肺癌炎性肿瘤微环境中的旁分泌调节与免疫系统通路：对肿瘤发生及免疫治疗策略的见解

Paracrine Regulation and Immune System Pathways in the Inflammatory Tumor Microenvironment of Lung Cancer: Insights into Oncogenesis and Immunotherapeutic Strategies.

作者信息

Batrash Firas, Shaik Adnan, Rauf Rayaan, Kutmah Mahmoud, Zhang Jun

机构信息

School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.

Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

出版信息

Cancers (Basel). 2024 Mar 10;16(6):1113. doi: 10.3390/cancers16061113.

DOI:10.3390/cancers16061113
PMID:38539448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10969565/
Abstract

The intricate interplay between inflammatory processes and the tumor microenvironment (TME) in lung cancer has garnered increasing attention due to its implications for both oncogenesis and therapeutic strategies. In this review, we explore recent advances in understanding the paracrine regulation and immune system pathways within the inflammatory TME of lung cancer. We delve into the molecular mechanisms underpinning oncogenesis, highlighting the role of immune cell populations, cancer-associated fibroblasts, and endothelial cells, as well as their interactions through immune system pathways regulated in a paracrine pattern. Additionally, we discuss emerging immunotherapeutic strategies with a specific focus on the potential of leveraging the inflammatory TME through these pathways to enhance treatment efficacy in lung cancer.

摘要

炎症过程与肺癌肿瘤微环境（TME）之间复杂的相互作用因其对肿瘤发生和治疗策略的影响而受到越来越多的关注。在本综述中，我们探讨了在理解肺癌炎症性TME内旁分泌调节和免疫系统途径方面的最新进展。我们深入研究了肿瘤发生的分子机制，强调了免疫细胞群体、癌症相关成纤维细胞和内皮细胞的作用，以及它们通过以旁分泌模式调节的免疫系统途径的相互作用。此外，我们讨论了新兴的免疫治疗策略，特别关注通过这些途径利用炎症性TME来提高肺癌治疗效果的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de01/10969565/f4c0fa7f495e/cancers-16-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de01/10969565/f4c0fa7f495e/cancers-16-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de01/10969565/f4c0fa7f495e/cancers-16-01113-g001.jpg

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本文引用的文献

1
Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines.肺癌患者的细胞因子谱：抗肿瘤和致癌细胞因子
Cancers (Basel). 2023 Nov 13;15(22):5383. doi: 10.3390/cancers15225383.
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SAPPHIRE: phase III study of sitravatinib plus nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer.SAPPHIRE 研究：西他拉替尼联合纳武利尤单抗对比多西他赛用于晚期非鳞状非小细胞肺癌。
Ann Oncol. 2024 Jan;35(1):66-76. doi: 10.1016/j.annonc.2023.10.004. Epub 2023 Oct 20.
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Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials.
定义肿瘤微环境中的癌症相关成纤维细胞（CAFs）：癌症免疫治疗的新机遇和临床试验的进展。
Mol Cancer. 2023 Oct 2;22(1):159. doi: 10.1186/s12943-023-01860-5.
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Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors.肺癌中的血管生成：了解生长因子的作用
Cancers (Basel). 2023 Sep 20;15(18):4648. doi: 10.3390/cancers15184648.
5
Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications.探讨肿瘤微环境中内皮细胞、免疫细胞和免疫检查点之间的串扰：新的见解和治疗意义。
Cell Death Dis. 2023 Sep 4;14(9):586. doi: 10.1038/s41419-023-06119-x.
6
AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages.AXL 启动的旁分泌激活 pSTAT3，增强肿瘤相关巨噬细胞的间充质和血管生成支持特征。
Cell Rep. 2023 Sep 26;42(9):113067. doi: 10.1016/j.celrep.2023.113067. Epub 2023 Sep 1.
7
Biomarkers for Immune Checkpoint Inhibitor Response in NSCLC: Current Developments and Applicability.非小细胞肺癌免疫检查点抑制剂反应的生物标志物：当前的发展和适用性。
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