一锅点击反应：串联对映选择性生物催化环氧化物开环和[3+2]叠氮炔环加成。
One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition.
机构信息
Stratingh Institute for Chemistry, University of Groningen, Groningen, the Netherlands.
出版信息
Chem Commun (Camb). 2010 Feb 14;46(6):898-900. doi: 10.1039/b919434g. Epub 2010 Jan 5.
DOI:10.1039/b919434g
PMID:20107643
Abstract
Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
摘要
卤代醇脱卤酶（HheC）可以对芳香环氧化物进行对映选择性叠氮化反应，生成 1,2-叠氮醇，然后与炔烃连接，在一锅法中生成手性羟基三唑，具有极好的对映体过量。
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