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蛋白酶介导的肽两亲物剧烈形态变化诱导超分子水凝胶形成。

Proteinase-mediated drastic morphological change of peptide-amphiphile to induce supramolecular hydrogelation.

机构信息

Department of Applied Chemistry, Graduate School of Engineering and Center for Future Chemistry, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan.

出版信息

Chem Commun (Camb). 2010 Feb 14;46(6):979-81. doi: 10.1039/b920359a. Epub 2009 Dec 11.

DOI:10.1039/b920359a
PMID:20107670
Abstract

We report a novel peptide-amphiphile having a simple molecular structure that can gelate an aqueous solution at a remarkably low concentration and can be designed to be responsive to a disease-related enzyme by undergoing a drastic morphological change.

摘要

我们报道了一种具有简单分子结构的新型肽两亲物，其在非常低的浓度下即可使水溶液凝胶化，并且可以通过发生剧烈的形态变化来设计成对与疾病相关的酶有响应。

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