National Skin Center, 1, Mandalay Road, Singapore 308205, Singapore.
Acta Derm Venereol. 2010;90(1):6-11. doi: 10.2340/00015555-0794.
Hypopigmentation disorders in children can be due to a wide variety of congenital and acquired diseases. A clinical approach to hypopigmentation disorders based on the typical age of onset and the extent of lesions is proposed. The disorders are categorized into onset in early and later childhood, and in each category they are subdivided into localized and generalized pigmentary disorders. Clinical findings, comprising the sites of involvement, degree of pigment loss, and associated morphological findings, are used to distinguish the disorders further. This classification provides a systematic approach to a clinical condition in which the causes are heterogeneous and histological examination of the skin is rarely diagnostic.
儿童色素减退性疾病可由多种先天性和获得性疾病引起。本文提出了一种基于发病年龄和皮损范围的儿童色素减退性疾病的临床分类方法。根据发病时间的早晚，将疾病分为早发型和晚发型；每一类再根据皮损的分布范围分为局限性和泛发性色素减退性疾病。根据皮损累及部位、色素脱失程度和伴随的形态学表现对疾病进行进一步鉴别，这些临床表现有助于对病因复杂且皮肤组织病理检查很少具有诊断性的疾病进行分类。
