MRC National Institute for Medical Research, Mill Hill, London, UK.
Semin Immunopathol. 2010 Mar;32(1):3-16. doi: 10.1007/s00281-009-0187-y. Epub 2010 Jan 27.
T helper (Th) 17 cells have been classified as a new lineage, distinct from Th1, Th2 and Treg. Their development requires a unique combination of cytokines and depends on distinct intracellular events, resulting in the production of the signature cytokines interleukin (IL)-17A, IL-17F and IL-22. The differential cytokine expression patterns in Th cells suggest a division of labour in the response against a variety of pathogens. Th17 have an important function in the host-defense-response against extracellular pathogens, but they also have become notorious for their role in the pathogenesis of many autoimmune and allergic disorders. Animal models of autoimmune disorders have shown that Th17 effector molecules and transcription factors play a crucial role in both development and maintenance of the disease. The discovery of Th17 not only enhanced our insight into these disorders but also placed a Th subset at the interface between the innate and adoptive immune systems with the potential to regulate subsequent immunity against pathogens.
辅助性 T 细胞 17（Th17）细胞已被归类为一个新的谱系，与 Th1、Th2 和 Treg 不同。它们的发育需要独特的细胞因子组合，并依赖于不同的细胞内事件，导致特征细胞因子白细胞介素（IL）-17A、IL-17F 和 IL-22 的产生。Th 细胞中不同的细胞因子表达模式表明在针对各种病原体的反应中有分工。Th17 在宿主防御反应中对抗细胞外病原体具有重要功能，但它们在许多自身免疫和过敏疾病的发病机制中的作用也变得臭名昭著。自身免疫疾病的动物模型表明，Th17 效应分子和转录因子在疾病的发展和维持中发挥着关键作用。Th17 的发现不仅增强了我们对这些疾病的认识，而且还将 Th 亚群置于先天和适应性免疫系统之间的界面上，具有调节随后对病原体的免疫的潜力。
