Shaw G L, Falk R T, Pickle L W, Mason T J, Buffler P A
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.
J Clin Epidemiol. 1991;44(4-5):429-37. doi: 10.1016/0895-4356(91)90082-k.
Family history data from an incident case-control study of lung cancer conducted in the Texas Gulf Coast region between 1976 and 1980 were analyzed to evaluate the contribution of cancer in first-degree relatives to lung cancer risk. Odds ratios (OR) increased slightly as the number of relatives with any cancer increased (reaching 1.5 with 4 or more relatives with cancer). Risks were higher for tobacco-related cancers (OR = 1.5 for 2 or more relatives with these tumors) and greatest for first-degree relatives with lung cancer (OR = 2.8 for lung cancer in 2 or more relatives). For cases of squamous cell carcinoma and adenocarcinoma of the lung, risks with 3 or more relatives with any cancer were increased 2-fold (OR = 1.8 and 1.9 respectively), and a significantly elevated risk was found for having a first-degree relative with lung cancer for each histologic type (ORs from 1.7-2.1). Having a spouse with lung cancer increased lung cancer risk (OR = 2.5), and cases with lung cancer reported in a first-degree relative were diagnosed at an earlier age, as were case siblings with lung cancer.
对1976年至1980年间在得克萨斯州墨西哥湾沿岸地区进行的一项肺癌病例对照研究中的家族史数据进行了分析，以评估一级亲属患癌对肺癌风险的影响。随着患任何癌症的亲属数量增加，比值比（OR）略有上升（有4个或更多患癌亲属时达到1.5）。与烟草相关癌症的风险更高（有2个或更多患这些肿瘤亲属时OR = 1.5），而一级亲属患肺癌时风险最高（有2个或更多亲属患肺癌时OR = 2.8）。对于肺鳞状细胞癌和腺癌病例，有3个或更多患任何癌症亲属时风险增加两倍（分别为OR = 1.8和1.9），并且每种组织学类型有一级亲属患肺癌时均发现风险显著升高（OR为1.7 - 2.1）。配偶患肺癌会增加肺癌风险（OR = 2.5），一级亲属中有肺癌病例的患者被诊断时年龄更早，有肺癌的病例同胞也是如此。
