Jin Yongtang, Xu Yingchun, Xu Ming, Xue Saoli
School of Public Health, Anhui Medical University, Hefei 230032, PR China.
BMC Cancer. 2005 Nov 11;5:146. doi: 10.1186/1471-2407-5-146.
Genetic factors were considered as one of the risk factors for lung cancer or other cancers. The aim of this work was to determine whether a genetic predisposition accounts for such familial aggregation of cancer among relatives of lung cancer probands.
A case-control study was conducted in 800 case families identified by lung cancer patients (probands), and in 800 control families identified by the probands'spouses. The data were analysed with logistic regression analysis model.
The data revealed a significantly greater overall risk of cancer (OR = 1.82, P < 0.01) in the proband group. The relatives of lung cancer probands maintained an increased risk of non-lung cancer (P < 0.05) after adjusting for confounder factors. The crude odds ratio of a proband family having one family member with cancer was 1.67 compared with control families. Proband families were 2.56 times more likely to have two other family members with cancer. For three cancers and four or more cancers, the risk increased to 3.50 and 5.91, respectively. The most striking differences in cancer prevalence between proband and control families were noted for cancer risk among female relatives. The strongest effects were for not only lung cancer in any female relatives (OR 2.17, 95%CI 1.60-3.64) and mothers (OR 2.78, 95%CI 1.23-5.12) and sisters (OR 2.03, 95%CI 1.26-3.97), but also non-lung cancer in females and mothers (OR 2.00, 95%CI 1.26-3.01, and OR 2.34, 95%CI 1.28-4.40, respectively).
These data support the hypothesis of a genetic susceptibility to cancer in families with lung cancer, and the female genetic susceptibility to cancer might be greater than male.
遗传因素被认为是肺癌或其他癌症的风险因素之一。本研究的目的是确定遗传易感性是否可解释肺癌先证者亲属中癌症的家族聚集现象。
对800个由肺癌患者（先证者）确定的病例家庭和800个由先证者配偶确定的对照家庭进行了病例对照研究。采用逻辑回归分析模型对数据进行分析。
数据显示先证者组患癌总体风险显著更高（比值比=1.82，P<0.01）。在调整混杂因素后，肺癌先证者的亲属患非肺癌的风险仍然增加（P<0.05）。与对照家庭相比，先证者家庭中有一名家庭成员患癌的粗比值比为1.67。先证者家庭中有另外两名家庭成员患癌的可能性是对照家庭的2.56倍。对于三名家庭成员患癌和四名及以上家庭成员患癌的情况，风险分别增至3.50和5.91。先证者家庭与对照家庭在癌症患病率上最显著的差异体现在女性亲属的癌症风险方面。最强的影响不仅体现在任何女性亲属患肺癌（比值比2.17，95%可信区间1.60 - 3.64）、母亲患肺癌（比值比2.78，95%可信区间1.23 - 5.12）和姐妹患肺癌（比值比2.03，95%可信区间1.26 - 3.97），还体现在女性患非肺癌、母亲患非肺癌（比值比分别为2.00，95%可信区间1.26 - 3.01和2.34，95%可信区间1.28 - 4.40）。
这些数据支持肺癌家族中存在癌症遗传易感性的假设，并且女性对癌症的遗传易感性可能大于男性。
