Schwartz A G, Yang P, Swanson G M
Department of Human Genetics, Allegheny-Singer Research Institute, Pittsburgh, PA 15212, USA.
Am J Epidemiol. 1996 Sep 15;144(6):554-62. doi: 10.1093/oxfordjournals.aje.a008965.
The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit. Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives. Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lung cancer among nonsmokers in the 40- to 59-year-old age group. This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk = 6.1, 95% confidence interval 1.1-33.4). Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk = 7.2, 95% confidence interval 0.5-103). A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives. These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset of relatives of early-onset nonsmoking cases.
在底特律市开展的一项基于人群的家庭研究中，评估了肺癌家族史在预测非吸烟者及其亲属患肺癌风险方面的作用。通过电话访谈收集了1984年至1987年间确诊的257例40 - 84岁非吸烟肺癌患者、他们的2252名亲属、277名非吸烟对照者以及他们的2408名亲属的肺癌风险因素数据。40至59岁年龄组的非吸烟者中，一级亲属患肺癌与患肺癌风险增加7.2倍（95%置信区间1.3 - 39.7）相关。在对每个家庭成员的吸烟史、职业史和病史进行调整后，这种显著增加的风险依然存在（相对风险 = 6.1，95%置信区间1.1 - 33.4）。非吸烟病例的后代构成了另一个肺癌高危组（相对风险 = 7.2，95%置信区间0.5 - 103）。60至84岁的非吸烟者及其亲属中，阳性家族史并未增加患肺癌风险。这些发现表明，非吸烟病例家庭中对肺癌的易感性可能仅在早发非吸烟病例的一部分亲属中表现明显。
