Delta-catenin 通过与 E-cadherin 竞争相互作用影响 p120-catenin 的定位和稳定性。
Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.
机构信息
The College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, 500-757, Korea.
出版信息
Mol Cells. 2010 Mar;29(3):233-7. doi: 10.1007/s10059-010-0030-2. Epub 2010 Jan 21.
Abstract
E-cadherin is a member of the cadherin family of Ca(2+)-dependent cell-cell adhesion molecules. p120-Catenin and delta-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and delta-catenin for E-cadherin has not been fully explained. In this report, we show that cells overexpressing delta-catenin contain less p120-catenin than control cells at the cell-cell interface and that this causes the relocalization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by either one to E-cadherin adversely affects the stability of the other.
摘要
E-钙黏蛋白是钙依赖细胞黏附分子钙黏蛋白家族的一员。已知 p120-连环蛋白和 δ-连环蛋白结合到 E-钙黏蛋白类似的质膜近侧区域，并且 p120-连环蛋白已知稳定 E-钙黏蛋白。然而，p120-连环蛋白和 δ-连环蛋白与 E-钙黏蛋白竞争的功能尚未完全解释。在本报告中，我们表明，过表达 δ-连环蛋白的细胞在细胞-细胞界面处含有比对照细胞更少的 p120-连环蛋白，这导致 p120-连环蛋白从质膜向细胞质重新定位。我们表明，两者之一与 E-钙黏蛋白的成功结合都会对另一个的稳定性产生不利影响。
相似文献
1
Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.Delta-catenin 通过与 E-cadherin 竞争相互作用影响 p120-catenin 的定位和稳定性。
Mol Cells. 2010 Mar;29(3):233-7. doi: 10.1007/s10059-010-0030-2. Epub 2010 Jan 21.
2
Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination.通过 p120 连环蛋白结合和 Hakai 介导的泛素化对 E-钙黏蛋白衔接区降解的竞争调节。
PLoS One. 2012;7(5):e37476. doi: 10.1371/journal.pone.0037476. Epub 2012 May 31.
3
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.p120 连环蛋白与 E-钙黏蛋白之间的动态和静态相互作用调节细胞间黏附的稳定性。
Cell. 2010 Apr 2;141(1):117-28. doi: 10.1016/j.cell.2010.01.017.
4
δ-Catenin dysregulation in cancer: interactions with E-cadherin and beyond.δ-连环蛋白在癌症中的失调：与 E-钙黏蛋白的相互作用及其他。
J Pathol. 2010 Oct;222(2):119-23. doi: 10.1002/path.2755.
5
Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin-p120-Catenin Complex.糖蛋白 90K 通过解离 E-钙黏蛋白-p120 连环蛋白复合物以细胞密度依赖的方式促进 E-钙黏蛋白降解。
Int J Mol Sci. 2017 Dec 2;18(12):2601. doi: 10.3390/ijms18122601.
6
Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.p120-连环蛋白和β-连环蛋白膜表达的同时丧失以及 E-钙黏蛋白减少与口腔癌进展相关。
PLoS One. 2013 Aug 6;8(8):e69777. doi: 10.1371/journal.pone.0069777. Print 2013.
7
Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas.前列腺癌中连环蛋白（α和β）、p120连环蛋白和E-钙黏蛋白细胞黏附蛋白的表达降低以及E-钙黏蛋白基因启动子甲基化
Cancer. 2001 Dec 1;92(11):2786-95. doi: 10.1002/1097-0142(20011201)92:11<2786::aid-cncr10128>3.0.co;2-i.
8
p120-Catenin is essential for N-cadherin-mediated formation of proper junctional structure, thereby establishing cell polarity in epithelial cells.p120连环蛋白对于N-钙黏蛋白介导的正常连接结构形成至关重要，从而在上皮细胞中建立细胞极性。
Cell Struct Funct. 2010;35(2):81-94. doi: 10.1247/csf.10009. Epub 2010 Sep 16.
9
DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.DIPA家族卷曲螺旋结构域结合p120连环蛋白家族保守的亚型特异性头部结构域：在脑积水和异位症中的潜在作用。
Mol Biol Cell. 2014 Sep 1;25(17):2592-603. doi: 10.1091/mbc.E13-08-0492. Epub 2014 Jul 9.
10
Numb controls E-cadherin endocytosis through p120 catenin with aPKC.麻木通过 p120 连环蛋白与 aPKC 控制 E-钙黏蛋白内吞作用。
Mol Biol Cell. 2011 Sep;22(17):3103-19. doi: 10.1091/mbc.E11-03-0274. Epub 2011 Jul 20.
引用本文的文献
1
δ-Catenin Participates in EGF/AKT/p21 Signaling and Induces Prostate Cancer Cell Proliferation and Invasion.δ-连环蛋白参与 EGF/AKT/p21 信号通路并诱导前列腺癌细胞增殖和侵袭。
Int J Mol Sci. 2021 May 18;22(10):5306. doi: 10.3390/ijms22105306.
2
Frequently rearranged and overexpressed δ-catenin is responsible for low sensitivity of prostate cancer cells to androgen receptor and β-catenin antagonists.频繁重排和过表达的δ-连环蛋白导致前列腺癌细胞对雄激素受体和β-连环蛋白拮抗剂敏感性降低。
Oncotarget. 2018 May 11;9(36):24428-24442. doi: 10.18632/oncotarget.25319.
3
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer.δ-Catenin 通过降低 c-Cbl 相互作用增加 EGFR 的稳定性，并增强前列腺癌中的 EGFR/Erk1/2 信号通路。
Mol Cells. 2018 Apr 30;41(4):320-330. doi: 10.14348/molcells.2018.2292. Epub 2018 Apr 5.
4
Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.表皮生长因子受体（EGFR）与δ-连环蛋白相互作用导致δ-连环蛋白磷酸化并增强EGFR信号传导。
Sci Rep. 2016 Feb 17;6:21207. doi: 10.1038/srep21207.
5
Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.相互连锁的正负反馈网络基序调节黏着连接途径中的β-连环蛋白活性。
Mol Biol Cell. 2015 Nov 5;26(22):4135-48. doi: 10.1091/mbc.E15-02-0083. Epub 2015 Jul 29.
6
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.近视相关 WNT7B 多态性的鉴定为近视发展机制提供了新的认识。
Nat Commun. 2015 Mar 31;6:6689. doi: 10.1038/ncomms7689.
7
DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.DIPA家族卷曲螺旋结构域结合p120连环蛋白家族保守的亚型特异性头部结构域：在脑积水和异位症中的潜在作用。
Mol Biol Cell. 2014 Sep 1;25(17):2592-603. doi: 10.1091/mbc.E13-08-0492. Epub 2014 Jul 9.
8
Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells.细胞因子信号传导抑制因子1调节结肠癌细胞的侵袭和转移潜能。
Mol Oncol. 2014 Jul;8(5):942-55. doi: 10.1016/j.molonc.2014.03.014. Epub 2014 Mar 25.
9
Delta-catenin promotes the proliferation and invasion of colorectal cancer cells by binding to E-cadherin in a competitive manner with p120 catenin.德尔塔连环蛋白通过与 p120 连环蛋白竞争结合 E-钙黏蛋白，促进结直肠癌细胞的增殖和侵袭。
Target Oncol. 2014 Mar;9(1):53-61. doi: 10.1007/s11523-013-0269-6. Epub 2013 Feb 20.
10
Association of paired box 6 with high myopia in Japanese.日本人群中配对盒基因6与高度近视的关联
Mol Vis. 2012;18:2726-35. Epub 2012 Nov 17.
本文引用的文献
1
Beta-catenin can bind directly to CRM1 independently of adenomatous polyposis coli, which affects its nuclear localization and LEF-1/beta-catenin-dependent gene expression.β-连环蛋白可独立于腺瘤性息肉病蛋白直接与CRM1结合，这会影响其核定位以及LEF-1/β-连环蛋白依赖性基因表达。
Cell Biol Int. 2008 Apr;32(4):394-400. doi: 10.1016/j.cellbi.2007.12.008. Epub 2008 Jan 9.
2
Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer.细胞周期蛋白依赖性激酶2/细胞周期蛋白E复合物参与p120连环蛋白（p120ctn）依赖性细胞生长调控：p120ctn在癌症中的新作用。
Cancer Res. 2007 Oct 15;67(20):9781-90. doi: 10.1158/0008-5472.CAN-07-0233.
3
Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer.δ-连环蛋白/神经原钙黏蛋白相关犰狳蛋白的表达增加与人类前列腺癌中E-钙黏蛋白和p120连环蛋白的下调及重新分布相关。
Hum Pathol. 2005 Oct;36(10):1037-48. doi: 10.1016/j.humpath.2005.07.012. Epub 2005 Sep 6.
4
Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.早老素-1 D257A和D385A突变体无法以其经内蛋白水解后的形式切割Notch，但只有早老素-1 D385A突变体能够通过正常C末端片段的补偿性过表达来恢复其γ-分泌酶活性。
J Biol Chem. 2005 Jun 10;280(23):22462-72. doi: 10.1074/jbc.M502769200. Epub 2005 Mar 29.
5
A core function for p120-catenin in cadherin turnover.p120连环蛋白在钙黏蛋白周转中的核心功能。
J Cell Biol. 2003 Nov 10;163(3):525-34. doi: 10.1083/jcb.200307111.
6
Altered expression of the catenin p120 in human cancer: implications for tumor progression.连环蛋白p120在人类癌症中的表达改变：对肿瘤进展的影响。
Differentiation. 2002 Dec;70(9-10):583-9. doi: 10.1046/j.1432-0436.2002.700911.x.
7
A novel role for p120 catenin in E-cadherin function.p120连环蛋白在E-钙黏蛋白功能中的新作用。
J Cell Biol. 2002 Nov 11;159(3):465-76. doi: 10.1083/jcb.200205115.
8
Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer.δ-连环蛋白和前列腺特异性膜抗原的表达分析：它们作为前列腺癌诊断标志物的潜力。
Int J Cancer. 2002 Jul 10;100(2):228-37. doi: 10.1002/ijc.10468.
9
Dendrite-like process formation and cytoskeletal remodeling regulated by delta-catenin expression.由δ-连环蛋白表达调控的树突状突起形成和细胞骨架重塑。
Exp Cell Res. 2002 May 1;275(2):171-84. doi: 10.1006/excr.2002.5503.
10
The control of beta-catenin and TCF during embryonic development and cancer.胚胎发育和癌症过程中β-连环蛋白和TCF的调控
Cancer Metastasis Rev. 1999;18(2):231-46. doi: 10.1023/a:1006321324190.
Zotero 插件