表皮生长因子受体（EGFR）与δ-连环蛋白相互作用导致δ-连环蛋白磷酸化并增强EGFR信号传导。

Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.

作者信息

He Yongfeng, Ryu Taeyong, Shrestha Nensi, Yuan Tingting, Kim Hangun, Shrestha Hridaya, Cho Young-Chang, Seo Young-Woo, Song Woo Keun, Kim Kwonseop

机构信息

College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju 500-757, Korea.

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon 540-742, Korea.

出版信息

Sci Rep. 2016 Feb 17;6:21207. doi: 10.1038/srep21207.

Expression of δ-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory prostate cancer. In this study, we investigated the possible correlation between EGFR and δ-catenin in prostate cancer cells. We found that EGFR interacted with δ-catenin and the interaction decreased in the presence of EGF. We also demonstrated that, on one hand, EGFR phosphorylated δ-catenin in a Src independent manner in the presence of EGF and on the other hand, δ-catenin enhanced protein stability of EGFR and strengthened the EGFR/Erk1/2 signaling pathway. Our findings added a new perspective to the interaction of EGFR to the E-cadherin complex. They also provided novel insights to the roles of δ-catenin in prostate cancer cells.

据报道，δ-连环蛋白的表达在前列腺癌晚期会增加。此外，已经证明表皮生长因子受体（EGFR）的表达在激素难治性前列腺癌中增强。在本研究中，我们调查了前列腺癌细胞中EGFR与δ-连环蛋白之间可能的相关性。我们发现EGFR与δ-连环蛋白相互作用，并且在表皮生长因子（EGF）存在的情况下这种相互作用减弱。我们还证明，一方面，在EGF存在的情况下，EGFR以不依赖Src的方式使δ-连环蛋白磷酸化；另一方面，δ-连环蛋白增强了EGFR的蛋白质稳定性并加强了EGFR/细胞外信号调节激酶1/2（Erk1/2）信号通路。我们的发现为EGFR与E-钙黏蛋白复合物的相互作用增添了新的视角。它们还为δ-连环蛋白在前列腺癌细胞中的作用提供了新的见解。