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雌激素缺乏导致的脂肪增加通过提高单核细胞趋化蛋白-1（MCP-1）的产生来诱导骨丢失。

Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production.

机构信息

Department of Biological Sciences (Brain Korea 21 Program) and the Immunomodulation Research Center, University of Ulsan, Ulsan, 680-749, Korea.

出版信息

Mol Cells. 2010 Mar;29(3):277-82. doi: 10.1007/s10059-010-0027-x. Epub 2010 Jan 21.

DOI:10.1007/s10059-010-0027-x
PMID:20108169
Abstract

Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production.

摘要

卵巢切除术（OVX）引起的雌激素缺乏会导致骨质流失和脂肪增加。我们观察到，用来自 OVX 小鼠而非假手术小鼠的脂肪处理骨髓来源的巨噬细胞后，破骨细胞（OC）的形成增加。OVX 小鼠的脂肪表达和分泌的单核细胞趋化蛋白-1（MCP-1）水平高于假手术小鼠。由于雌激素缺乏导致的脂肪增加是由于 OC 形成增强导致骨质流失的原因，至少部分原因是 MCP-1 产生增加的结果。

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