Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Mov Disord. 2010 Mar 15;25(4):496-9. doi: 10.1002/mds.22975.
The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.
帕金森病（PD）的病理学不仅局限于脑干区域，还会扩散到涉及新皮层区域。使用基于表面的皮质厚度分析，我们研究了轻度 PD 非痴呆患者皮质变薄的地形分布。高分辨率磁共振成像（MRI）研究在 48 名无痴呆的 PD 患者和 56 名年龄匹配的健康对照者中进行。使用 Freesurfer 软件进行基于表面的分析，以寻找 PD 患者大脑皮质厚度的变化。与对照组相比，PD 患者在颞叶、下顶叶、额前回和眶额皮质区域表现出明显的皮质变薄。即使在轻度 PD 非痴呆患者中，也会发生大脑皮层变薄，其地形分布与新皮层路易体相似。需要进一步研究以发现轻度 PD 非痴呆患者变薄的大脑皮层的病理和临床相关性。
