Department of Neurology, Philipps-University, Marburg, Germany.
Mov Disord. 2010 Feb 15;25(3):349-56. doi: 10.1002/mds.22966.
Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population-based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age-standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01-10.15] for PD, 0.11 (95% CI 0.03-0.23) for multiple system atrophy, 0.14 (95% CI 0.08-0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01-0.12) for corticobasal degeneration. The age-standardized male-to-female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male-to-female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD.
在东欧国家和亚洲，有关帕金森病（PD）和非典型帕金森综合征（APS）发病率的数据有限。本前瞻性人群研究的目的是确定俄罗斯人群中 PD 和 APS 的发病率。研究区域是莫斯科的一个拥有 123.79 万居民的大区。采用多种病例发现来源来确定 2006 年 7 月至 2008 年 12 月期间新发的 PD 和 APS 病例。所有新发病例均由专家进行检查，并进行前瞻性随访以确认诊断。标准化发病率（每 10 万人/年）为 9.03（95%置信区间 8.01-10.15），其中 PD 为 0.11（95%置信区间 0.03-0.23），多系统萎缩为 0.14（95%置信区间 0.08-0.21），进行性核上性麻痹为 0.02（95%置信区间 0.01-0.12），皮质基底节变性为 0.02（95%置信区间 0.01-0.12）。所有年龄和 60 岁及以上年龄组 PD 的男女标准化比例为 0.87。新发 PD（34%）和 APS（50%）病例中，相当大比例的患者伴有抑郁症状。鉴于东欧和亚洲老年人口的快速增长，应更深入地研究这些地区 PD 和 APS 的流行病学。我们的研究中 PD 的发病率略低于西方人群的研究，男女比例更接近亚洲人群的研究报告。本研究的临床意义在于强调需要更好地诊断和治疗 PD 早期的抑郁症状。
