Huo M H, Troiano N W, Pelker R R, Gundberg C M, Friedlaender G E
Department of Orthopaedics & Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06510.
J Orthop Res. 1991 May;9(3):383-90. doi: 10.1002/jor.1100090310.
Ibuprofen is a widely used cyclo-oxygenase inhibitor in clinical practice. It has been demonstrated by others to have an inhibitory effect on fracture repair in animals. In the present study, we were unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague-Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12-week time interval. Fracture histology and serum osteocalcin levels were no different in treated animals than control animals. Furthermore, histomorphometric parameters of bone remodeling, including bone volume and bone formation rate in the intact tail vertebrae of these animals with unilateral femur fractures, were no different between treated and control animals.
布洛芬是临床实践中广泛使用的环氧化酶抑制剂。其他人已证明它对动物骨折修复有抑制作用。在本研究中，我们未能证明，在成熟的Sprague-Dawley大鼠骨折后3天开始，以30毫克/千克/天的口服剂量给予布洛芬，持续12周的时间间隔，通过扭转试验和骨折阶段测量的骨折生物力学有任何显著变化。治疗组动物的骨折组织学和血清骨钙素水平与对照组动物没有差异。此外，在这些单侧股骨骨折的动物完整尾椎中，包括骨体积和骨形成率在内的骨重塑组织形态计量学参数，治疗组和对照组动物之间没有差异。
