Mersin University, Education Faculty Yenisehir Campus 33169 Mersin, Turkey.
J Environ Sci (China). 2009;21(5):696-9. doi: 10.1016/s1001-0742(08)62326-8.
The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.
对甲基对硫磷的致突变和致癌作用进行了研究，采用细菌回复突变试验和 Wistar 大鼠长期试验。在没有大鼠肝 S9 代谢激活的情况下，观察到甲基对硫磷对鼠伤寒沙门氏菌 TA100 细菌细胞的潜在致突变作用。进一步研究了甲基对硫磷对大鼠胰腺和肝脏的病理变化。长期大鼠实验表明，甲基对硫磷暴露 3 个月可导致大鼠胰腺腺泡细胞和胰腺肝细胞的病理变化。在大鼠的肝和胰腺中发现了不典型腺泡细胞灶（AACF）。短期 Ames 试验和长期大鼠实验结果表明，甲基对硫磷具有潜在致癌性。
