Jabbar A, Khawaja S A, Iqbal A, Malik S A
Entomological Research Labs., National Agricultural Research Centre, Islamabad.
J Pak Med Assoc. 1990 Nov;40(11):266-70.
The effect of sub-lethal doses of Malathion and Methyl-parathion was studied on the rat liver enzymes. Intravenous administration of both insecticides at weekly interval for four weeks resulted in increase in heart and spleen weight. Short term (24 hr.) and long term (4 weeks) treatment with insecticides resulted in increased specific activities of liver enzymes, Acid phosphatase, Alkaline phosphatase, Glutamate dehydrogenase, Glutamate oxaloacetate transaminase and Glutamate pyruvate transaminase. The increase in enzyme activity was not as profound when the insecticide administration was spread over 4 weeks. Malathion had greater effect than Methyl-parathion on the biochemical parameters studied.
研究了亚致死剂量的马拉硫磷和甲基对硫磷对大鼠肝脏酶的影响。每周静脉注射这两种杀虫剂，持续四周，导致心脏和脾脏重量增加。杀虫剂短期（24小时）和长期（4周）处理导致肝脏酶、酸性磷酸酶、碱性磷酸酶、谷氨酸脱氢酶、谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶的比活性增加。当杀虫剂给药时间延长至4周时，酶活性的增加并不那么显著。马拉硫磷对所研究的生化参数的影响比甲基对硫磷更大。
