Gazi University, Vocational High School of Health Services, Gölbaşı, 06830 Ankara, Turkey.
Ecotoxicol Environ Saf. 2011 Oct;74(7):2112-8. doi: 10.1016/j.ecoenv.2011.07.001. Epub 2011 Jul 22.
Male rats were given vitamins C+E, methyl parathion, or both daily via gavage for seven weeks. Body weight was decreased while liver weight increased significantly at the end of fourth and seventh weeks in the methyl parathion- and methyl parathion plus vitamin-treated groups. Serum total protein, albumin, triglyceride, low density lipoprotein-cholesterol (VLDL-cholesterol) levels decreased, and serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl-transferase (GGT), lactate dehydrogenase (LDH), and total cholesterol levels increased significantly in the methyl parathion- and the methyl parathion plus vitamin-treated rats. There was a statistically significant difference for all biochemical parameters when the methyl parathion plus vitamin-treated group was compared with methyl parathion-treated group. In electron microscopic investigation, cytopathological alterations were observed in hepatocytes of the methyl parathion- and the methyl parathion plus vitamin-treated rats. As a result, methyl parathion-induced hepatotoxicity is reduced by vitamins C+E, but vitamins C+E did not provide complete protection.
雄性大鼠通过灌胃每日给予维生素 C+E、甲基对硫磷或两者，持续 7 周。在第四周和第七周结束时，甲基对硫磷和甲基对硫磷加维生素处理组的体重减轻，而肝重显著增加。血清总蛋白、白蛋白、甘油三酯、低密度脂蛋白胆固醇（VLDL-胆固醇）水平降低，血清碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转移酶（GGT）、乳酸脱氢酶（LDH）和总胆固醇水平在甲基对硫磷和甲基对硫磷加维生素处理的大鼠中显著升高。与甲基对硫磷处理组相比，甲基对硫磷加维生素处理组的所有生化参数均有统计学差异。在电子显微镜检查中，观察到甲基对硫磷和甲基对硫磷加维生素处理的大鼠肝细胞的细胞病理改变。因此，维生素 C+E 可减轻甲基对硫磷引起的肝毒性，但维生素 C+E 并不能提供完全的保护。
