多形性胶质母细胞瘤的当前数据与策略
Current data and strategy in glioblastoma multiforme.
作者信息
Iacob Gabriel, Dinca Eduard B
机构信息
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
出版信息
J Med Life. 2009 Oct-Dec;2(4):386-93.
Abstract
Glioblastoma multiforme (GBM) or astrocytoma grade IV on WHO classification is the most aggressive and the most frequent of all primary brain tumors. Glioblastoma is multiforme, resistant to therapeutic interventions illustrating the heterogeneity exhibited by this tumor in its every aspect, including clinical presentation, pathology, genetic signature. Current data and treatment strategy in GBM are presented focusing on basic science data and key clinical aspects like surgery, including personal experience; adjuvant modalities: radiotherapy, chemotherapy, but also for experimental approaches. Therapeutic attitude in recurrent GBM is also widely discussed.
摘要
多形性胶质母细胞瘤（GBM）或世界卫生组织分类中的IV级星形细胞瘤是所有原发性脑肿瘤中最具侵袭性且最常见的。胶质母细胞瘤形态多样，对治疗干预具有抗性，这表明该肿瘤在各个方面都表现出异质性，包括临床表现、病理学、基因特征。本文介绍了GBM的当前数据和治疗策略，重点关注基础科学数据以及手术等关键临床方面，包括个人经验；辅助治疗方式：放疗、化疗，还有实验方法。复发性GBM的治疗态度也得到了广泛讨论。
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