[人乳头瘤病毒脱氧核糖核酸基因分型检测在非典型鳞状细胞中的意义]

[The significance of HPV-DNA genotyping assays in the ASC].

作者信息

Biu Hui, Zhao Jian, Li Ke-Min, Liao Qin-Ping

机构信息

Department of Obs and Gyn, Peking University First Hospital, Beijing 100034, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Aug;23(4):296-8.

PMID:20108778

Abstract

OBJECTIVE

To disscuss different outcomes of ASC-UC and ASC-H, two subtypes of ASC, and the significance of HPV-DNA genotyping assays in these two subtypes.

METHODS

We reviewed and analyzed colposcopic and biopsy results of 1256 cases of ASC between Jan. 2005 to Dec. 2007, of which 580 cases have results of HPV-DNA genotyping assays.

RESULTS

In 1256 ASC cases, ASC-US and ASC-H cases account for 90.1% and 9.9% respectively, CIN2 and higher levels diagnosed via colposcopy and cervical biopsy are 8.5% and 24.2% respectively (P = 0.000). In ASC-US cases, the infection rate of HPV-DNA high risk types is 67.2%, there is statistic significance among different HPV-DNA results and biopsy pathology (P = 0.000). In ASC-H cases, the infection rate of HPV-DNA high risk types is 47.3%, there is no statistic significance among them (P = 0.054).

CONCLUSION

The clinical outcomes of ASC-US and ASC-H are different, we should distinguish and treat. HPV-DNA genotyping assay is available in ASC-US triage, but Colposcopy is proposed for all ASC-H patients.

摘要

目的

探讨非典型鳞状细胞不明确意义（ASC-UC）和非典型鳞状细胞不除外高度病变（ASC-H）这两种非典型鳞状细胞（ASC）亚型的不同转归，以及HPV-DNA基因分型检测在这两种亚型中的意义。

方法

回顾性分析2005年1月至2007年12月间1256例ASC患者的阴道镜及活检结果，其中580例有HPV-DNA基因分型检测结果。

结果

1256例ASC患者中，ASC-US和ASC-H分别占90.1%和9.9%，经阴道镜及宫颈活检诊断的CIN2及以上病变分别为8.5%和24.2%（P = 0.000）。ASC-US患者中，HPV-DNA高危型感染率为67.2%，不同HPV-DNA检测结果与活检病理之间存在统计学差异（P = 0.000）。ASC-H患者中，HPV-DNA高危型感染率为47.3%，它们之间无统计学差异（P = 0.054）。