Kearney H, Delanty N
Department of Neurology, Beaumont Hospital, Beaumont, Dublin.
Ir Med J. 2009 Nov-Dec;102(10):326-8.
Felbamate (FBM) is efficacious in treating patients with refractory epilepsy but was withdrawn due to cases of aplastic anaemia, hepatic failure and five reported deaths. FBM is currently used in specialist centres and is only being used in one Irish centre to date. This papers aim is to review the efficacy and safety experience of FBM in Irish adult patients with refractory epilepsy. A retrospective chart review was done on patients' medical records. Patients were subdivided into responders and non responders based on change in seizure frequency and side effects were recorded for all. Of the 13 patients on FBM nine patients responded to FBM, four patients did not. FBM is a safe and efficacious alternative in an Irish adult population with refractory epilepsy. However close monitoring is still required given the potential fatal side effects that are possible with this anticonvulsant.
非氨酯（FBM）对治疗难治性癫痫患者有效，但因出现再生障碍性贫血、肝衰竭病例以及五例报告死亡病例而被撤市。FBM目前在专科中心使用，迄今为止仅在爱尔兰的一个中心使用。本文旨在回顾FBM在爱尔兰成年难治性癫痫患者中的疗效和安全性经验。对患者的病历进行了回顾性图表审查。根据癫痫发作频率的变化将患者分为反应者和无反应者，并记录所有患者的副作用。在使用FBM的13例患者中，9例对FBM有反应，4例无反应。在爱尔兰成年难治性癫痫患者中，FBM是一种安全有效的替代药物。然而，鉴于这种抗惊厥药可能存在潜在的致命副作用，仍需要密切监测。
