Odell E W, Segal A W
Department of Oral Medicine and Pathology, UMDS, Guy's Hospital, London.
J Med Microbiol. 1991 Mar;34(3):129-35. doi: 10.1099/00222615-34-3-129.
The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans, a less frequent pathogen in patients with CGD, was much more susceptible.
通过在人中性粒细胞初级颗粒裂解物中孵育，评估了与慢性肉芽肿病（CGD）相关的机会性病原体对中性粒细胞非氧化杀伤机制的敏感性。烟曲霉、白色念珠菌、大肠杆菌、星状诺卡菌、粘质沙雷菌和金黄色葡萄球菌的杀伤剂量和pH依赖性存在显著差异，这可能部分解释了它们在CGD中的毒力，在CGD中氧依赖性杀伤机制存在缺陷。在CGD中性粒细胞吞噬体的酸性pH条件下，金黄色葡萄球菌、粘质沙雷菌、星状诺卡菌和烟曲霉孢子具有高度抗性，但白色念珠菌（CGD患者中较少见的病原体）则更易被杀伤。
