慢性轻度应激期间，NC/Nga 特应性小鼠湿疹皮肤的神经支配减少。
Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress.
机构信息
Karolinska Institutet, Department of Medicine Solna, Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm Sweden.
出版信息
Immunopharmacol Immunotoxicol. 2010 Mar;32(1):147-52. doi: 10.3109/08923970903219633.
BACKGROUND AND AIM
A connection between chronic mild stress and altered innervation in the skin of an atopic mouse strain, NC/Nga, was studied.
MATERIAL AND METHODS
We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized).
RESULTS
There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis.
CONCLUSION
Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.
背景与目的
研究了慢性轻度应激与变应性小鼠品系 NC/Nga 皮肤神经支配改变之间的关系。
材料与方法
我们使用了三组小鼠，应激对照组（SC，应激但未用螨抗原免疫）、非应激湿疹组（NSE，未应激但免疫）和应激湿疹组（SE，应激和免疫）。
结果
与 SC 小鼠相比，SE 小鼠的表皮和真皮中 PGP9.5 阳性神经纤维减少，与 NSE 小鼠相比，SE 小鼠的 GAP-43 阳性神经纤维也减少。
结论
特应性小鼠的慢性轻度应激导致湿疹病变中神经支配减少。
Zotero 插件