The Medical Food Research and Development Center, Department of Transfusion Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Int J Food Sci Nutr. 2010 May;61(3):295-305. doi: 10.3109/09637480903455963.
The present study was to investigate in vitro alpha-glucosidase, pancreatic alpha-amylase and protein glycation inhibitory activities of nine edible plants. The results indicated that total phenolics, flavonoids, and condensed tannins of nine edible plants showed marked variations, ranging from 12.2 to 80.1 mg gallic acid equivalent/g extract, 2.34 to 13.65 mg quercetin equivalent/g extract, and 97.2 to 460.1 mg catechin equivalent/g extract, respectively. Our findings showed that grape seed, Cat's whiskers and Sweetleaf extract were the most effective pancreatic alpha-amylase, intestinal maltase, and sucrase inhibitor with IC(50) values of 0.29 +/- 0.01 mg/ml, 0.97 +/- 0.10 mg/ml and 0.86 +/- 0.01 mg/ml, respectively. All extracts (1 mg/ml) markedly inhibited the glycation of bovine serum albumin in fructose-mediated non-enzyme glycation by 50-30% at week 1. It was found that Pennywort maintained the high percentage inhibition among those of the extracts during the 4 weeks of experiment. These edible plants may be used for controlling blood glucose level and prevention of the development of type 2 diabetes.
本研究旨在探讨九种食用植物的体外α-葡萄糖苷酶、胰α-淀粉酶和蛋白质糖化抑制活性。结果表明，九种食用植物的总酚、类黄酮和缩合单宁含量差异显著，范围分别为 12.2 至 80.1 mg 没食子酸当量/g 提取物、2.34 至 13.65 mg 槲皮素当量/g 提取物和 97.2 至 460.1 mg 儿茶素当量/g 提取物。研究结果表明，葡萄籽、猫须草和甜叶菊提取物对胰α-淀粉酶、肠麦芽糖酶和蔗糖酶的抑制作用最强，IC50 值分别为 0.29 ± 0.01、0.97 ± 0.10 和 0.86 ± 0.01 mg/ml。所有提取物（1mg/ml）在 1 周的果糖介导的非酶糖化中均能显著抑制牛血清白蛋白的糖化，抑制率为 50-30%。在 4 周的实验过程中，发现积雪草能保持较高的抑制率。这些食用植物可能用于控制血糖水平和预防 2 型糖尿病的发生。
