The Medical Food Research and Development Center, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Plant Foods Hum Nutr. 2011 Jun;66(2):143-8. doi: 10.1007/s11130-011-0226-4.
Inhibition of α-glucosidase and pancreatic α-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose. The aim of this study was to evaluate the phytochemical analysis and the inhibitory effect of various cinnamon bark species against intestinal α-glucosidase and pancreatic α-amylase. The results showed that the content of total phenolic, flavonoid, and condensed tannin ranged from 0.17 to 0.21 g gallic acid equivalent/g extract, from 48.85 to 65.52 mg quercetin equivalent/g extract, and from 0.12 to 0.15 g catechin equivalent/g extract, respectively. The HPLC fingerprints of each cinnamon species were established. Among cinnamon species, Thai cinnamon extract was the most potent inhibitor against the intestinal maltase with the IC(50) values of 0.58 ± 0.01 mg/ml. The findings also showed that Ceylon cinnamon was the most effective intestinal sucrase and pancreatic α-amylase inhibitor with the IC(50) values of 0.42 ± 0.02 and 1.23 ± 0.02 mg/ml, respectively. In addition, cinnamon extracts produced additive inhibition against intestinal α-glucosidase and pancreatic α-amylase when combined with acarbose. These results suggest that cinnamon bark extracts may be potentially useful for the control of postprandial glucose in diabetic patients through inhibition of intestinal α-glucosidase and pancreatic α-amylase.
抑制α-葡萄糖苷酶和胰α-淀粉酶是延缓碳水化合物消化、降低餐后血糖的治疗方法之一。本研究旨在评估不同肉桂树皮品种的植物化学分析和对肠道α-葡萄糖苷酶和胰α-淀粉酶的抑制作用。结果表明，总酚、类黄酮和缩合单宁的含量范围分别为 0.17 至 0.21 g 没食子酸当量/g 提取物、48.85 至 65.52 mg 槲皮素当量/g 提取物和 0.12 至 0.15 g 儿茶素当量/g 提取物。建立了每种肉桂品种的 HPLC 指纹图谱。在肉桂品种中，泰国肉桂提取物对肠道麦芽糖酶的抑制作用最强，IC（50）值为 0.58 ± 0.01 mg/ml。研究还表明，锡兰肉桂是最有效的肠道蔗糖酶和胰α-淀粉酶抑制剂，IC（50）值分别为 0.42 ± 0.02 和 1.23 ± 0.02 mg/ml。此外，肉桂提取物与阿卡波糖联合使用对肠道α-葡萄糖苷酶和胰α-淀粉酶具有相加抑制作用。这些结果表明，肉桂树皮提取物通过抑制肠道α-葡萄糖苷酶和胰α-淀粉酶，可能对糖尿病患者餐后血糖的控制具有潜在的应用价值。
