Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy.
Curr Pharm Des. 2010 Jan;16(3):277-91. doi: 10.2174/138161210790170139.
Metabolic immune restraints belong to a highly complex network of molecular mechanisms underlying the failure of naturally occurring and therapeutically induced immune responses against cancer. In the light of the disappointing results yielded so far with anticancer vaccines in the clinical setting, the dissection of the cascade of molecular events leading to tumor immune escape appears the most promising way to develop more effective immunotherapeutic strategies. Here we review the significant advances recently made in the understanding of the tumor-specific metabolic features that contribute to keep malignant cells from being recognized and destroyed by immune effectors. These mechanistic insights are fostering the development of rationally designed therapeutics aimed to revert the immunosuppressive circuits and thus to enhance the effectiveness of anticancer vaccines.
代谢免疫抑制属于一个高度复杂的分子机制网络，该网络是天然发生和治疗性诱导的抗肿瘤免疫反应失败的基础。鉴于目前临床应用的抗肿瘤疫苗所产生的令人失望的结果，解析导致肿瘤免疫逃逸的级联分子事件似乎是开发更有效的免疫治疗策略的最有希望的方法。在这里，我们综述了最近在理解肿瘤特异性代谢特征方面取得的重大进展，这些特征有助于使恶性细胞逃避免疫效应细胞的识别和破坏。这些机制上的见解促进了合理设计治疗药物的发展，旨在逆转免疫抑制回路，从而提高抗肿瘤疫苗的有效性。
