Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Am J Rhinol Allergy. 2010 Jan-Feb;24(1):e37-40. doi: 10.2500/ajra.2010.24.3408.
The etiology of sinonasal inverted papilloma (IP) is unknown. This study was designed to evaluate the possible risk factors associated with IP Methods: This is a case-control epidemiology study in a tertiary referral center. Fifty patients with IP and 150 matched controls were interviewed using a questionnaire on suspected risk factors. Univariate analysis of the risk factors and calculation of the matched odds ratios, the corresponding 95% CIs, and p values was performed. Significant risk factors were further studied using conditional logistic regression analysis.
Outdoor and industrial occupations were associated with IP. Tobacco smoking, drinking alcohol, history of allergic rhinitis, sinusitis, nasal polyp, non-sinonasal papilloma and non-sinonasal malignancy were not significant factors.
Outdoor and industrial occupations were associated with IP and may be potential risk factors. Future studies are warranted to further evaluate the individual type of occupation and chemical involved.
鼻窦内翻性乳头状瘤（IP）的病因尚不清楚。本研究旨在评估与 IP 相关的可能危险因素。
这是在三级转诊中心进行的病例对照流行病学研究。对 50 例 IP 患者和 150 例匹配对照者进行问卷调查，以评估可疑的危险因素。对危险因素进行单因素分析，并计算匹配优势比、相应的 95%置信区间和 p 值。使用条件 logistic 回归分析进一步研究有意义的危险因素。
户外和工业职业与 IP 相关。烟草使用、饮酒、变应性鼻炎、鼻窦炎、鼻息肉、非鼻窦内翻性乳头状瘤和非鼻窦恶性肿瘤不是显著的危险因素。
户外和工业职业与 IP 相关，可能是潜在的危险因素。需要进一步的研究来评估具体的职业类型和涉及的化学物质。
