Sham Cheuk Lun, Lee Dennis L Y, Hasselt C Andrew van, Tong Michael C F
Am J Rhinol Allergy. 2010 Jan 1;24(1):37-40. doi: 10.2500/ajra.2010.24.3408.
The etiology of sinonasal inverted papilloma (IP) is unknown. This study was designed to evaluate the possible risk factors associated with IP Methods: This is a case-control epidemiology study in a tertiary referral center. Fifty patients with IP and 150 matched controls were interviewed using a questionnaire on suspected risk factors. Univariate analysis of the risk factors and calculation of the matched odds ratios, the corresponding 95% CIs, and p values was performed. Significant risk factors were further studied using conditional logistic regression analysis.
Outdoor and industrial occupations were associated with IP. Tobacco smoking, drinking alcohol, history of allergic rhinitis, sinusitis, nasal polyp, non-sinonasal papilloma and non-sinonasal malignancy were not significant factors.
Outdoor and industrial occupations were associated with IP and may be potential risk factors. Future studies are warranted to further evaluate the individual type of occupation and chemical involved.
鼻窦内翻性乳头状瘤（IP）的病因尚不清楚。本研究旨在评估与IP相关的可能危险因素。方法：这是一项在三级转诊中心进行的病例对照流行病学研究。使用关于可疑危险因素的问卷对50例IP患者和150例匹配对照进行访谈。对危险因素进行单因素分析，并计算匹配比值比、相应的95%置信区间和p值。使用条件逻辑回归分析进一步研究显著危险因素。
户外和工业职业与IP相关。吸烟、饮酒、过敏性鼻炎、鼻窦炎、鼻息肉、非鼻窦乳头状瘤和非鼻窦恶性肿瘤病史不是显著因素。
户外和工业职业与IP相关，可能是潜在危险因素。有必要进行进一步研究以进一步评估具体的职业类型和所涉及的化学物质。
