向核心运动：基于微管的马达蛋白在构建有丝分裂纺锤体中间区中的作用。
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.
机构信息
Department of Obstetrics and Gynecology, and Robert H. Lurie Cancer Center, Northwestern University School of Medicine, Chicago, IL 60611, USA.
出版信息
Semin Cell Dev Biol. 2010 May;21(3):290-9. doi: 10.1016/j.semcdb.2010.01.017. Epub 2010 Jan 28.
Abstract
In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.
摘要
在哺乳动物培养细胞中，细胞分裂的起始受到纺锤体中间区重叠的反平行微管的调节——无论是在时间上还是在空间上。这个区域招募了几个关键的中心纺锤体成分：PRC-1、Polo 样激酶 1（Plk-1）、中心纺锤体复合物和染色体乘客复合物（CPC），它们共同稳定微管重叠，并协调组装皮质肌动球蛋白细胞骨架，这对于物理上分裂细胞是必需的。这些关键元件在纺锤体中间区的定位需要基于微管的运动蛋白驱动蛋白超家族的成员。在这里，我们重点回顾了各种驱动蛋白在细胞分裂过程中构建和操作纺锤体中间区机械装置中的作用。
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